Efficacy and Safety of Exenatide Once WeeklyVersusMetformin,Pioglitazone, and Sitagliptin Used asMonotherapy in Drug-Naive PatientsWith Type 2 Diabetes (DURATION-4) A 26-week double-blind study

نویسندگان

  • DAVID RUSSELL-JONES
  • ROBERT M. CUDDIHY
  • MARKOLF HANEFELD
  • ANNE M. WOLKA
  • MARILYN K. BOARDMAN
چکیده

RESEARCH DESIGN AND METHODSdPatients were randomized to subcutaneous (SC) EQW 2.0 mg + oral placebo (n = 248), MET 2,000 mg/day + SC placebo (n = 246), PIO 45 mg/day + SC placebo (n = 163), or SITA 100 mg/day + SC placebo (n = 163) for 26 weeks. MET and PIO therapies were increased to maximum-tolerated dosages. Injections with EQW or placebo were administered weekly, while oral medication or placebo was administered daily.

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تاریخ انتشار 2011